Ursolic acid, also known as ursolic acid and ursolic acid, is a pentacyclic triterpenoid compound extracted from the evergreen creeping shrub bearberry of the Rhododendron family. It has a special smell and is large and shiny in absolute ethanol. Prisms, but fine hair-like needles in dilute ethanol. mp285℃～288℃, D20+66°(pyridine), easily soluble in dioxane, pyridine, soluble in methanol, ethanol, butanol, butanone, slightly soluble in acetone, slightly soluble in benzene, chloroform , ether, insoluble in water and petroleum ether. It has various biological effects such as sedative, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, and lowering blood sugar.
Let’s learn about its benefits.
1. Liver protection, anti-hepatitis effect
Its clinical manifestations have the effect of significantly and rapidly reducing alanine aminotransferase, serum aminotransferase, remission of jaundice, increasing appetite, anti-fibrosis and restoring liver function
Indian scholar Saraswat et al found that ursolic acid (5-20 mg•kg) had a protective effect on CC1-induced hepatotoxicity in rats. Using it as pretreatment can significantly improve the survival rate of rat hepatocytes, and it has been observed in the experiment that it has the effect of anti-cholestasis, and the bile flow and its contents are increased. Based on the mechanism of action of CC1, it is speculated that the therapeutic mechanism of ursolic acid on damaged hepatocytes may be similar to its isomer oleanolic acid, which is to protect and stabilize the biofilm system of liver cell membranes and organelles, making them permeable and active. The transport function returned to normal, the movement and distribution of ions and water inside and outside the cells also recovered, and the regeneration ability was successively restored, which promoted the repair of necrotic liver cells in the central area of the liver lobule.
2. Anti-tumor effect
It also has resistance to a variety of carcinogenic and cancer-promoting substances. Studies have found that it can inhibit the proliferation of human tongue squamous cell carcinoma cell line TSCCa cells, and the inhibitory dose to half of the growth of TSCCa cells is about 12.5 μmol•L-1, within 24 hours. It showed a certain dose-effect relationship; in situ hybridization showed that the inhibitory effect of ursolic acid on TSCCa cells was related to the inhibition of the in situ expression of nuclear transcription factors. . In vivo experiments have shown that ursolic acid can significantly enhance the immune function of the body.
It has preventive and inhibitory effects on various stages of tumor formation and growth, inhibiting tumor formation and growth and inducing cancer cell differentiation. Guevara and other studies showed that ursolic acid can reduce the number of micronucleated red blood cells in polychromatin induced by mutagen by 76%. The results of Ohigachi et al. showed that ursolic acid had an inhibitory effect on the activation of Raji cells EBA-EA induced by phorbol ester (TPA), the degree of which was almost the same as that of retinoic acid, and the survival rate of Raji cells was higher than that of the group treated with retinoic acid. The mechanism is that Effectively block the link between TPA and receptor binding.
3. Antioxidant
Wholesale Ursolic Acid Powder is a strong antioxidant. Experiments have shown that ursolic acid can inhibit the activities of 5-lipoxygenase and cyclooxygenase in the process of arachidonic acid metabolism, and prevent the production of prostaglandins and leukotrienes. This may be because it inhibits inflammation and inhibits lipid peroxides. s reason. Subbaramaiah and other studies have shown that ursolic acid can inhibit the transcription of cyclooxygenase in human mammary epithelial cells, thereby inhibiting the production of prostaglandins.
Its antioxidant effect has a positive effect on the human body‵s anti-aging, skin freckle, and pigment removal. As a cosmetic, it has stable properties, its color and smell do not change with time, and it has a good touch, so it has a wide range of applications in beauty and skin care products.
4. Antibacterial, anti-inflammatory and antiviral
Tapondjou et al. confirmed through acetic acid writhing test and hot plate method that ursolic acid and hydroxyursolic acid have similar anti-inflammatory and bacteriostatic effects. It also has trypanicidal activity, and after 2 h incubation at a concentration of 2 g·L, the activity of T. cruzi flagella was completely inhibited.
It can lead to decreased cell viability.
5. The effect of lowering blood lipid, anti-atherosclerosis and lowering blood sugar
It can reduce blood cholesterol (44%) and B-lipoprotein levels (50%) in rabbits and rats, and has hypolipidemic and anti-atherosclerotic effects. Ursolic acid can improve liver and kidney yin deficiency, tinnitus, dry mouth, less sleep, irritability, numbness and fear of cold, constipation caused by dyslipidemia. The total effective rate of blood lipids is 95%.
6. Suppression of HIV
Tian Ying et al. have proved through clinical trials that ursolic acid has a strong inhibitory effect on HIV-1 protease activity, and its 50% inhibitory concentration (IC50) is 8 μmol/L. HIV-1 protease is a homodimeric enzyme, which may inhibit the activity of HIV-1 protease by inhibiting the dimerization of HIV-1 protease, thereby inhibiting HIV-1 protease.
7. Anti-diabetic, anti-ulcer
8. Sedative and tranquilizing effect
9. Enhance immune function
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