Wholesale Ursolic Acid Powder is a triterpenoid compound present in natural plants. It has various biological effects such as sedation, anti-inflammatory, antibacterial, anti-diabetic, anti-ulcer, and lowering blood sugar. Ursolic acid also has obvious antioxidant function. , so it is widely used as raw materials for medicine and cosmetics.
Production process
The pulverized loquat leaves or privet leaves are extracted by refluxing with ethanol to obtain a fluid extract-like extract, and the ethanol is recovered. The above-mentioned extract is fully washed with water and dried to obtain a dry extract. The dry extract is dissolved in ethanol and decolorized. The decolorizing solution After recovering ethanol, add water to precipitate a large amount of precipitates, adjust the pH value to 2-2.5, separate and collect the precipitates, wash with water until neutral, and vacuum dry to obtain a crude extract whose main component is ursolic acid.
In vitro studies
Several studies have shown that it induces apoptosis in a variety of cancer cells and enhances the anticancer activity of conventional drugs, and there are several mechanisms by which ursolic acid can sensitize cancer cells to chemotherapeutic drugs. One of the targets is NF-κB, and scientists found that ursolic acid not only induced apoptosis of pancreatic cancer cells, but also increased the apoptosis of gemcitabine by downregulating NF-κB.
In addition, it and its derivatives may enhance the therapeutic effect of chemotherapeutic drugs by synergistically inhibiting glucose metabolism in cancer cells; it also regulates autophagy by inducing the accumulation of LC3 and p62 levels, and synergistically reduces the activity of melanoma cells; it can also increase the The therapeutic effect of cisplatin plays an important role in the occurrence and development of bladder cancer; in addition, several molecular inhibitors can also be used in combination with UA to increase the sensitivity of cancer cells to exert its chemosensitizing properties.
At present, scientists have detected the chemosensitizing effect of ursolic acid in animal models, and research reports have shown that ursolic acid exhibits significant chemosensitizing effects on a variety of cancer types. In addition, ursolic acid sensitizes the therapeutic drug capecitabine by inhibiting multiple biomarkers related to inflammation, proliferation, invasion, angiogenesis, and metastasis, and has the potential to improve the efficacy of traditional drugs. Therefore, preclinical studies suggest that combining ursolic acid with other natural compounds, conventional drugs or radiation may be an effective combination for the treatment of cancer.
Many experimental systems have reported that it has various biochemical and pharmacological effects such as anti-inflammatory, anti-oxidative, anti-proliferative, anti-cancer, anti-mutation, anti-atherosclerosis, anti-hypertension, anti-leukemia and anti-virus; UA can not only enhance cancer The chemosensitivity of cells can also enhance the effects of other chemotherapeutic agents on liver injury, glucose intolerance and insulin resistance, acne vulgaris, hyperlipidemia, biofilm formation, myocyte differentiation, depression and neurodegenerative diseases.
It is also thought to improve skin health, forming a protective film on the surface of the hair, like the waxy protective film found on fruits or plants. According to Naringin.net, it is used to treat skin photoaging because it inhibits the appearance of wrinkles and age spots and restores the skin‵s collagen bundle structure and elasticity. Ursolic acid inhibits the activity of elastase in the skin, preventing this Different types of enzymes destroy structural proteins.
Clinical application
Li Kaiquan et al. have found that UA is used alone or in combination with other drugs in the preparation of drugs for the treatment of viral hepatitis, as long as it is prepared as a drug or a health care drug, it has a significant effect on the treatment of viral hepatitis. In addition, Tan Renxiang et al. also confirmed that UA not only has the effect of treating viral hepatitis, but also has antidepressant effect, and the perilla extract containing UA is used as a drug for the treatment of depression. UA has almost no adverse reactions. Compared with western medicine, it has a narrower antidepressant spectrum, more toxic and side effects, and has significant advantages such as easy relapse and suicidal tendency after medication. Capsules made of privet leaf extract with UA as the main component are mainly used for primary hyperlipidemia caused by liver and kidney yin deficiency and yin deficiency and yang hyperactivity. It is a second-class new drug approved in my country.
Purpose
This product can be used as an emulsifier for pharmaceutical and cosmetic raw materials and food.
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