Bulk 98% Phloretin Powder is a new type of natural skin whitening agent recently researched and developed abroad. It is mainly from in the peel of apples. It is widely used in facial masks, skin creams, lotions and essences. It can inhibit the excessive secretion of sebaceous glands for the treatment of exuberant acne; it can inhibit the activity of melanocytes and has an effect on various skin pigmentation. Compared with similar natural ingredients arbutin and kojic acid, the same concentration of phloretin has better inhibitory effect on tyrosinase, and when it is compounded with arbutin and (or) kojic acid, it can effectively inhibit tyrosinase. Greatly improve the product’s inhibition rate of tyrosinase, so as to achieve the effect of whitening. Phloretin has a very strong moisturizing effect, can absorb 4 to 5 times its own weight of water, can promote the absorption and utilization of other functional factors in the formula, so that it can play a better effect; its antioxidant function is also very strong, can clear the skin free radicals within. Let’s learn about it together!
1. Anti-aging and antioxidant activity
It is a flavonoid of dihydrochalcone structure with 4 phenolic hydroxyl groups, and its unique structure determines its strong antioxidant activity. In vitro experiments show that it has the ability to inhibit mitochondrial lipid peroxidation, scavenge DPPH free radicals and ABTS free radicals.
Studies have shown that it has strong antioxidant activity, with an antioxidant mass concentration of 10.30 mg/L to oil, which can scavenge free radicals in the skin. It not only has antioxidant effect on its own, but also can be used in combination with existing antioxidants to improve the antioxidant effect. The study found that a combination of 34.9% ferulic acid, 35.1% phloretin, and 30% water-soluble V had a synergistic antioxidant effect. At the same time, scholars have solved the problems of poor water solubility and stability of it by using O/W microemulsion technology and embedding technology, providing guidance for its application in cosmetics. It can be seen that high quality 98% Phloretin Powder has a good free radical scavenging effect and has great application prospects in anti-aging cosmetics.
2. Anti-inflammatory activity
In vitro studies have shown that it can inhibit the production of inflammatory factors, chemokines and differentiation factors, and has a certain anti-inflammatory effect. At the same time, the study found that it can inhibit the phosphorylation of single Akt and MAPK, so as to achieve anti-inflammatory effect. It has also been shown to have antioxidant and anti-inflammatory effects in in vivo studies. Its anti-inflammatory effects in vitro and in vivo suggest that it has a potential soothing effect and can be used in soothing skin care products.
3. Sun protection
Studies have found that it has a certain ability to absorb ultraviolet rays, and adding it to the basic formula of cosmetics can improve the SPF and SPA values of cosmetics. In addition, the phloretin, V and ferulic acid blend protects human skin from UV rays and provides photoprotection to human skin. It can not only directly absorb ultraviolet rays, but also enhance the expression of nucleotide excision repair genes, slow down the formation of pyrimidine dimers, glutathione degradation and cell death induced by UVB, and reduce the damage of ultraviolet rays to keratinocytes.
Ultraviolet radiation can cause cells to generate reactive oxygen species and free radicals, which are extremely unstable and prone to a series of oxidative chain reactions that eventually damage cells. It has antioxidant activity and absorbs ultraviolet rays, and has potential application value in sunscreen cosmetics.
4. Promotes transdermal absorption
It is a lipophilic compound that penetrates into the skin via intercellular lipids. Studies have shown that it changes the membrane dipole potential of the phospholipid bilayer, affecting the interfacial organization of the phospholipid bilayer and the osmotic-driven water flow dynamics of water. The cream has good transdermal properties.
At the same time, when it was used as a medium, the transdermal absorption of lidocaine hydrochloride increased to 5.4 times of the original, indicating that it can affect the transport process mediated by the carrier and has a certain function of promoting transdermal absorption. It is a natural, safe and effective lipophilic compound with a certain effect of promoting penetration. It can be added to cosmetics as a carrier of effective active ingredients to promote the transdermal absorption of active ingredients and make it play a better role. effect.
5. Antibacterial activity
It is a flavonoid compound with bacteriostatic activity. The study found that it has a strong inhibitory effect on Gram-positive bacteria, especially on Staphylococcus aureus (ATC6538, MIC=7.81 mg/L), Listeria (ATCC 13932, MIC=62.5 mg/L) and murine Salmonella typhi (ATCC 13111, MIC=125 mg/L). In addition to its bacteriostatic activity against pathogenic bacteria, it also has an effect on common bacteria on the skin. Its MIC for Propionibacterium acnes and P. acnes granules were both 0.5 mg/L, and the clinical test results showed that the subjects had significant whiteheads, blackheads, papules and sebum secretion after using it for 4 weeks. , indicating that it has a potential acne-relieving effect.
On the one hand, its inhibitory effect on bacteria is to act on the enzyme protein system inside the bacteria, affecting the energy metabolism of bacteria and the oxidative damage repair of bacterial growth; cause bacterial death. To sum up, it has a certain bacteriostatic effect. With the in-depth study of its bacteriostatic effect, it may be developed as a new natural bacteriostatic agent added to cosmetics to replace some chemical preservatives, and can also be used as a natural antibacterial agent. Functional ingredients are added to acne-fighting cosmetics.
6. Whitening activity
Studies have found that it has the effect of inhibiting tyrosinase activity, and its Ic∞ is 37.5 txmol/L. 0.3% of its inhibition rate of tyrosinase is as high as 98.2%, and its inhibition of amino acid is better than that of common whitening agents (kojic acid and arbutin). Further research found that it is comparable to common tyrosinase Inhibitor compounding can greatly improve its inhibition rate, and achieve 100% inhibition effect well. In addition, the inclusion complex of hydroxypropyl cyclodextrin and it also has a good inhibitory effect on tyrosinase activity.
7. Moisturizing
The 4 hydroxyl groups contained in its molecule can form hydrogen bonds with water molecules to absorb water and have a potential moisturizing effect. Therefore, 98% Phloretin Powder for sale can also be used as a natural moisturizer in moisturizing cosmetics.
8. Anti-hair loss effect
Studies have shown that it can inhibit the activity of soybean lipoxygenase, thereby reducing the loss of hair due to premature aging, indicating that it has a potential anti-hair loss effect and can be added to shampoo and conditioner as an anti-hair loss raw material.
9. Antitumor activity
Studies have found that it induces tumor cell apoptosis by inhibiting the transport of glucose in tumor cells. Studies have found that it can inhibit the proliferation of cancer cells and induce their apoptosis in a concentration- and time-dependent manner. It can block the cell cycle in the G1 phase, by affecting the cell cycle, reducing the mitochondrial membrane potential, and changing the intracellular calcium ion balance. Induce apoptosis of cancer cells.
10. Improve vascular endothelial dysfunction and disorders
The higher choline group in the other group can significantly reduce the serum levels of total cholesterol, triacylglycerol, alanine aminotransferase, aspartate aminotransferase, endothelin-1 and thromboxane A2, and significantly antagonize the serum prostacyclin and NO levels. Improve vascular endothelial function. In addition, it can enhance the activities of superoxide dismutase and glutathione peroxidase in the liver, reduce the level of malondialdehyde, and histopathological experiments also demonstrated the protective effect of it on the liver.
Other studies have shown that it can act on ion channels in cells, inhibit the influx of calcium ions through potential-dependent calcium channels or inhibit the release of calcium ions from the endoplasmic reticulum induced by phosphoinositide 3, thereby affecting the contraction of the aorta, play a role in protecting blood vessels.
11. Membrane absorption promotion
It is a lipophilic compound, and it has a certain effect on the cell membrane, which can affect the carrier-mediated transport process. Studies have shown that it can inhibit the activity of melanocytes, has a lightening effect on various skin pigmentation, and has a good inhibitory effect on tyrosinase. It is a very safe and effective freckle whitening agent. In vitro tyrosinase activity test It was shown that it inhibited tyrosinase activity in a competitive and dose-dependent manner.
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