Kojic acid, the chemical name is 5-hydroxy-2-hydroxymethyl-1,4-pyrone, exists in the brewing of soy sauce, bean paste, and wine, and can be detected in many fermented products fermented with Aspergillus its existence. It is a weak acid compound produced by fermentation with small molecular weight, which can be directly absorbed through the skin and has a high utilization rate. It can prevent the production of tyrosinase, thereby inhibiting the production of melanin, and blocking the production of melanin. Let’s learn about it together!
Whitening mechanism:
The whitening mechanism of Pure 99% Kojic Acid Powder is to directly inhibit the tyrosinase that causes melanin melanin, preventing melanin melaninization (polymerization).
In the skin irradiated with ultraviolet rays, the tyrosine amino acids in the melanocytes of the basal layer combine with the tyrosinase active enzyme to become dopa, and after the dopa binds to the tyrosinase, it becomes dopaquinone, A portion of dopaquinone becomes eumelanin (melanin).
The whitening mechanism of Wholesale 99% Kojic Acid Powder is to supplement the copper element necessary for the work of tyrosinase to block the activity of tyrosinase and prevent it from contacting with tyrosine, thereby inhibiting tyrosinase It has the effect of inhibiting the production of DHICA and DHI, the main precursor monomers of melanin, to achieve the effect of whitening and skin care.
Kojic acid safety:
In the early 1990s, Japan took the lead in adding kojic acid to cosmetics as a whitening ingredient, mainly using its inhibitory effect on tyrosinase and blocking of melanin production intermediates to whiten the skin and remove pigmentation. Subsequent studies found that it may have a carcinogenic risk. In 2003, the Japanese government banned the import and reproduction of cosmetics containing kojic acid. Later, due to insufficient evidence, the regulations for adding it to cosmetics were reopened in 2005. Although there is no clear restriction on use, it is recommended The dosage is between 0.1% and 1% by mass fraction.
Toxicity kinetic studies in rats show that kojic acid is rapidly absorbed and distributed to various organs after oral, dermal or subcutaneous administration, and the metabolic rate of oral and subcutaneous administration is faster than that of skin exposure, and the metabolites are mainly sulfuric acid and glucose. Conjugates of uronic acid and kojic acid metabolites are present in the liver and kidneys and are mainly excreted in the urine. In recent years, many foreign scholars have carried out a lot of research on its genotoxicity, carcinogenicity, embryotoxicity and teratogenicity, and mutagenicity of genetic material. In the range of 1000～l500 mg/kg. In the range of oral dose of 300-1000 mg/(kg·d), whether in male or female rats, various clinical physiological and biochemical indicators are normal, no effect was found in necropsy and microscopic observation, only lymphocytes and leukocytes. slightly lower. The intraperitoneal route of administration was used, and the dose of kojic acid was 300 mg/kg each time. After 14 days, the rats developed hepatotoxicity and pathological phenomenon. However, the results of studies on its effects on fertility and embryos in rats are uncertain.
Whether kojic acid has a mutagenic effect on the genetic material of organisms, except that it can induce mutations in the genes of certain strains of Salmonella and Bacillus subtilis, different researchers have obtained different conclusions. Numerous studies have shown that it induces thyroid hyperplasia independent of the genotoxic pathway. Sustained high doses can inhibit the absorption of iodine in mice and rats, and induce thyroid hyperplasia and adenoma. Adding kojic acid to food may have the risk of inducing thyroid tumors, but the current test is limited to mice and rats, and there is no Other animal test evidence. However, the concentration of kojic acid in food is extremely low, and it should be safe to use under normal circumstances.
Main functions and uses
1. Used in industry to make cosmetics
It can inhibit the synthesis of tyrosinase, so it can strongly inhibit the formation of skin melanin, and it is safe and non-toxic, and will not produce vitiligo sequelae, so it has been formulated into lotions, masks, lotions, and skin creams. High-grade whitening cosmetics that effectively treat freckles, age spots, hyperpigmentation, acne, etc. At a concentration of 20ug/ml, it can inhibit 70-80% of the activity of various tyrosinase (or polyphenol oxidase PPO), and the general addition amount in cosmetics is 0.5-2.0%.
2. For food processing
99% Kojic Acid Powder for sale can be used as a food additive for preservation, antiseptic and anti-oxidation. Experiments have shown that it can inhibit the conversion of sodium nitrite in bacon into carcinogenic nitrosamines, and adding it to food will not affect the taste, aroma and texture of food; it is also the raw material for the production of maltol and ethyl maltol. In food processing, the application range is very wide.
3. For medicinal purposes
Since it has no mutagenic effect on eukaryotic cells, it can also eliminate free radicals in the human body and enhance the power of white blood cells, which is beneficial to human health. Therefore, it has been used as the raw material of cephalosporin antibiotics, and the finished medicines produced are used for the treatment of headache, Toothache and local inflammation and other diseases, the analgesic and anti-inflammatory effects are very ideal.
4. Agricultural pesticides
It can be used to produce biological pesticides. The biological micro-fertilizer (dark red liquid) made by adding 0.5-1.0% kojic acid, whether it is sprayed at a low concentration as a foliar fertilizer, or made into a growth and yield-increasing agent for root application, this crop production promoter is effective for food and Vegetables have obvious effect of increasing yield.
Our Bulk 99% Kojic Acid Powder is high quality with enough stock. we guarantee our products are produced in strict according to standard and specification. We are constantly developing more products to meet market demand, if you have any requirements, please contact us freely. Email: info@lonierherb.com Whatsapp/Wechat: +86-18189137076
