Wholesale Dipotassium Glycyrrhizate Powder is a white or off-white powder, easily soluble in water, soluble in ethanol, and insoluble in oil and triterpenoid saponins. It contains hydrophilic groups and lipophilic groups, which can reduce the surface tension of aqueous solutions, It has strong foaming power, and has the effects of emulsifying, dispersing, moisturizing hair, softening skin, anti-wrinkle, anti-sebum, preventing and controlling pigmentation, anti-inflammatory and antipruritic, and washing and decontamination. It is widely used in medicine, daily chemicals, food, etc. industry. As a cosmetic functional additive such as anti-allergy, sunscreen, freckle removal, and skin repair, it can effectively prevent skin irritation and inflammation, and has anti-inflammatory and sedative effects on inflammation caused by sunlight.
【Physical and chemical properties】
Molecular formula: C42H60K2O16
Molecular weight: 899.13
Dipotassium glycyrrhizate is white powder, sweet in taste, soluble in water, soluble in glycerol, propylene glycol, slightly soluble in absolute ethanol and ether.
【Mechanism of action】
1. Whitening
Bulk Dipotassium Glycyrrhizate Powder can inhibit the production of melanin. The experimental study selected the back skin of guinea pigs. Under UVB irradiation, the skin pretreated with 0.5% product had a higher whiteness coefficient (L value) than the skin of the control group, and the effect was significant. The experimental results It has been shown to significantly inhibit melanin production, which can be used to prevent skin pigmentation and melanin production after sun exposure, and is a potential skin lightening agent.
2. Anti-allergic effect
It acts on hormone receptors on the cell membrane, affects ion channels, activates or inhibits enzyme activity, regulates substance metabolism and the excitability of cholinergic nerves, thereby reducing the permeability of capillary walls and cell membranes to reduce inflammation. The purpose of sexual exudation, and inhibit the formation and release of histamine and other toxic substances, so as to play a good anti-inflammatory effect.
It can inhibit the production of histamine and have a very good effect on skin redness and itching, especially for certain anaphylactic shocks. The basic unit between the stimuli that cause itching and the impulses that occur in free nerve endings is the mediator with physiological activity. Among them, histamine is the material basis of pruritus, and any factor that stimulates mast cells can degranulate mast cells to release histamine, thereby triggering itching. Therefore, the clinical use of antihistamines and stabilizing mast cells to reduce histamine release can treat common itching. Itching is a common complication of skin sensitivity. Its main allergens and action routes are similar to allergic reactions. , Dipotassium glycyrrhizate inhibits the occurrence of type I hypersensitivity reaction, which can greatly reduce the incidence of itching.
3. Regulate immune function
It has mineralocorticoid (Mineralocorticoid)-like effects---sodium retention and potassium excretion and glucocorticoid (Glucocorticoid)-like effects---glucose metabolism, but long-term use has no side effects.
Direct effect: It is generally believed that the chemical structure of glycyrrhetic acid in it is similar to that of adrenocortical hormone (Cortin), which affects ion channels and activates or inhibits enzyme activity by acting on the hormone receptor (Receptor) on the cell membrane. Regulates substance metabolism and regulates the excitability of cholinergic nerves. As a result, the permeability of capillary walls and cell membranes is reduced, the inflammatory exudation is reduced, and the formation and release of histamine and other toxic substances are inhibited, thus playing a good anti-inflammatory effect.
Indirect effect: that is, the glycyrrhetic acid in dipotassium glycyrrhizate inhibits the destruction of adrenal cortex hormones in the body, so that its content in the blood increases accordingly, thereby enhancing the body‵s resistance to inflammation.
4. It also has a very good therapeutic effect on trauma. It can effectively remove superoxide ions and free radicals and can be used together with other active agents in cosmetics. It can effectively promote the skin‵s absorption of cosmetics, and enhance the efficacy and role of cosmetics. Sunscreen products, whitening products and anti-allergic anti-itching products will also appear. In addition, it also appears in many moisturizing products or hair growth and hair care products and products that regulate sebum. Even if you use it for a long time, you don‵t have to worry about side effects. In fact, the ingredients of this product can also be seen in our usual skin care water or toner, shower gel, freckle cream, facial mask, etc. It has a very good cosmetic skin care effect, and can also effectively achieve anti-inflammatory and antibacterial effects. It is helpful for the treatment of many skin diseases. In addition, many eye drops and ointments for stomatitis will also appear in toothpaste.
【Nursing applications】
It is not only suitable for hair and skin care, but also for oral hygiene care.
skin care:
Whitening - Inhibits melanin production and brightens skin tone. Anti-inflammatory - suitable for the treatment of skin inflammations such as wounds, eczema, burns, etc., and care for sensitive, fragile and irritable skin.
Oral Care:
For the treatment of gingival inflammation, oral hygiene and tooth protection.
Scalp Care:
Relieves itchy scalp.
We are Dipotassium Glycyrrhizate Powder manufacturers . Each batch of the goods can be shipped to you after strict inspection. For the further information , please contact and enquiry to us immediately, your satisfaction is our first priority. THANK YOU !
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