Wholesale Usnea Acid Powder is currently the most important and one of the most widely distributed lichenic acids, also known as lichenic acid. According to reports, the former Soviet Union made usnic acid into various dosage forms in the 1960s, and it was widely used in the treatment of wounds, burns, chapped and other diseases. Because of its strong antibacterial, anti-radiation, antiseptic and other effects, usnic acid has been used in medicine, perfume, cosmetics and other industries, and it is added as a pure substance to toothpaste, mouthwash, deodorant, sunscreen oil and weight loss products. Products etc. In recent years, the research on usnic acid has mostly focused on antibacterial, antiviral, insecticidal, antitumor, anti-inflammatory and other aspects. Let‵s find out how it works together!
1. Antibacterial effect
It can effectively inhibit the growth of Gram-positive bacteria such as Staphylococcus aureus, MRSA, acne bacillus, and corynebacterium, and can inhibit the growth of Pityrosporum furfur, directly kill the cells of Staphylococcus aureus, and hinder the growth of Pseudomonas aeruginosa The signal transduction pathway suggests that the Usnea grandis extract and Usnenic acid can be used to treat acne, rosacea, seborrheic dermatitis and other related skin diseases; in addition, it can eliminate sa drug-resistant plasmids, and its elimination rate is 52% after 24 hours of action. Prolonging the action time to 48h, the elimination rate can reach 14.6%, which may be used in the clinical treatment of drug-resistant sa infection.
2. Antiviral effect
Studies have shown that it has the potential to inhibit the proliferation of mouse polyomavirus, mainly by inhibiting the formation of messenger RNA, thereby indirectly inhibiting the replication of DNA.
3. Insecticidal effect
It has the activity of killing Leishmania donovani (Kala-azar) promastigotes, and the in vitro activity concentration of (+)-usnicic acid is 25 μg/mL. The minimum effective concentration of S-(-) usnic acid to kill trichomoniasis in vitro is 0.4 mg/mL, and there is no significant difference in the in vitro trichomoniasis killing effect between usnic acid at a concentration of 0.4 mg/mL and above and the same concentration of metronidazole. In 5-30μg/mL, usnic acid has a growth inhibitory effect on trypanosome larvae, and it can also significantly reduce the amount of trypanosomes in the blood. Use 40 or 80μg/mL usnic acid to act on infected macrophages , can lead to the disintegration of trypanosome mitochondria and Golgi apparatus, and the cytoplasm becomes vacuolated, but has no effect on the host cell.
4. Anti-tumor effect
Study the inhibitory effect of usnic acid extracted from the fungus Usnea on the proliferation of prostate cancer PC-3M cells cultured in vitro. The results of cell growth inhibition experiments show that the maximum inhibition rate of Chemicalbook can reach more than 80%, and the biological effect is dose-dependent The inhibitory relationship shows that it has an inhibitory effect on PC-3M cells cultured in vitro, slows down the proliferation of tumor cells, and has obvious anti-tumor effects. But it has no inhibitory effect on 12(S)-LOX cultured with human platelets in vitro. Usnenic acid has poor water solubility, and it uses 10%HP-β-CD as a solubilizer to investigate the influence on three kinds of human malignant cell lines under the condition of pH7.4. The solubility in medium was increased by 70 times, and the EC50 for T-47D, Panc-1 and PC-3 cells were 2.9μg/mL, 4.3μg/mL and 8.2μg/mL, respectively.
5. Anti-inflammatory activity
Use, rat foot swelling test (acute inflammation) and rat cotton ball granuloma test (chronic inflammation) to carry out anti-inflammatory activity research on usnic acid, with ibuprofen as positive control drug, the results show that acute inflammation, in and Under the same dose of ibuprofen (oral 100mg/kg), the anti-inflammatory effect of ibuprofen is better than that of usnic acid; for chronic inflammation, the anti-inflammatory effect of the two is equivalent, and there is a significant difference compared with the control group. It is speculated that the anti-inflammatory effect of usnic acid The mechanism of inflammation is related to the inhibition of prostaglandin synthesis.
6. Other activities
Studies have shown that it has the effect of promoting skin wound healing. The overall experiment shows that external application of sodium usnicate can accelerate the repair of experimental large skin damage, but it has no promoting effect on the proliferation of L929 fibroblasts at 0.5-8 μg/mL. In addition, the effect of sodium usnenate on fibroblasts and its mechanism of promoting wound healing were investigated, and the results showed that it could promote the secretion of TGF-1 and EGF by fibroblasts, and it was enhanced with the increase of drug concentration. Produce chemotactic effect on repair cells and inflammatory cells, promote repair cell migration and deposition of extracellular matrix, and promote wound healing. In addition, experimental studies have shown that usnic acid has a better gastric protection effect on the gastric ulcer model of rats induced by indomethacin. Compared with the model group, it can significantly increase the levels of SOD, GSH and GPx in rats, reduce the level of LPO, and increase cNOS, reduce iNOS. In terms of anti-radiation, the research on the absorption of lichen secondary metabolites in the UV region shows that usnic acid mainly absorbs in the UV-B region and is relatively stable to light. And the photolysis product of usnic acid still has absorption effect on UV, suggesting that it is a very potential natural sunscreen agent, which can be used in cosmetics such as sunscreen oil.
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