Wholesale St John′s Wort Extract Powder is made from dried Hypericum perforatum flowering tip or aboveground part through extraction, filtration, crystallization, purification and other processes. The appearance is dark brown or tan powder . It has the effects of antibacterial and anti-inflammatory, astringent and hemostasis, regulating menstruation and promoting blood circulation, reducing swelling and relieving pain. The traditional application fields mainly focus on sedation, anti-inflammation, wound healing and so on. Hypericum perforatum contains a variety of chemical components, and pharmacological experiments have shown that a variety of chemical components have certain biological activities. Different biologically active components in Hypericum perforatum have different pharmacological effects, and each component exerts synergistic effects with each other to treat different diseases.
1. Antidepressant effect
In the early 19th century, German physician Kemer discovered that Hypericum perforatum could treat emotional disorders. Since then, Bulk St John′s Wort Extract Powder has long been used as a treatment for skin surface wounds and an antidepressant in Europe. Especially since the 1980s, the ingredients of Hypericum perforatum have become more and more research hotspots for foreign medical workers, and the most convincing one is the drug containing hypericin in the treatment of mild and moderate depression patients. The therapeutic effect of Hypericum perforatum extract is significantly better than placebo, and compared with standard antidepressants (tricyclics), the curative effect and side effects are small.
2. Antiviral effect
As early as the 1980s, Memel et al reported the anti-HIV reverse transcriptase effect of hypericin: Hypericin 2 ug/rnl was cultured with HIV, and the results showed that the HIV reverse transcriptase activity was reduced by 75%. De-clervp believes that the anti-HIV mechanism of hypericin may be to inhibit reverse transcriptase, and hypericin does not affect the transcription and translation of the virus, but interferes with the virus. Gao Ying et al. studied the interaction between hypericin and HIV virus reverse transcriptase at the molecular level to explore the antiviral mechanism of hypericin compounds, and their research can provide a theoretical model for the drug design of HIV virus inhibitors and important references. Hypericum Perforatum Extract has certain antiviral effects on enveloped virus, hepatitis B and hepatitis C viruses, in addition to its certain effect on AIDS.
3. Antibacterial effect
Physician Li Hong and others reported that the total extract of Hypericum perforatum has strong antibacterial and bactericidal effects on Brevibacterium flavum, Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, and Bacillus thuringiensis 7216. It has strong antibacterial and bactericidal effects on 11 Gram-positive bacterial strains that are resistant to commonly used antibiotics isolated clinically, suggesting that the extract can be used to control clinically resistant Gram-positive bacterial strains that are resistant to multiple antibiotics. Infections caused by Lambert-positive strains.
4. Anti-tumor and anti-cancer effects
Hyperforin can inhibit the growth of MT-450 breast cancer cells, and the mechanism may be that hyperforin activates the mitochondria-mediated signal transduction pathway, thereby inducing tumor cell apoptosis. Hypericin has inhibitory effect on the growth of leukemia cell lines K562 and U937 and malignant glioma cell line LN229, and confirmed the synergistic effect of hypericin and hypericin in inhibiting the growth of K562 and U937 cells.
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