Phloretin is a new natural skin whitening agent, mainly distributed in the peel and root bark of apples, pears and other juicy fruits.It can absorb four to five times its own weight in water and has a very potent moisturizing effect. It can promote the absorption and utilization of other functional factors in the formula, so that they can exert better effects. It has a strong antioxidant function and can remove free radicals in the skin. The antioxidant concentration of oil is between (10~30)×10-6. It can prevent sugar components from entering epidermal cells, thereby inhibiting excessive secretion of cutaneous glands and treating acne with strong secretion; it can inhibit the activity of melanocytes and have a lightening effect on various skin spots. Phloretin can be used in facial masks, skin care creams, lotions and essences.
1) Antioxidant and anti-free radical effects
Phlorizin 98% for sale is an excellent natural antioxidant. The 2,6-dihydroxyacetophenone structure has a very good antioxidant effect. It has an obvious effect on scavenging peroxynitrite and is resistant to grease. The oxidation concentration is between 10 and 30PPm, which can remove free radicals in the skin. And because its hydroxyl group at position 6 is replaced by a glucosidyl group, its antioxidant activity is greatly reduced.
2) Whitening - inhibit tyrosinase activity
Phloretin is a reversible mixed inhibitor of tyrosinase. It has the ability to alter tyrosinase's secondary structure, which lowers the enzyme‵s catalytic activity and keeps it from binding to its substrate. Some studies have found that phloretin has a better inhibitory effect on tyrosinase than common whitening agents (arbutin, etc.).
Moreover, L-dopa was utilized as a substrate in certain investigations to quantify the inhibitory impact of various inhibitor concentrations on tyrosinase‵s bisphenolase activity. Phloretin was shown to have a stronger inhibitory effect on tyrosinase than phloridzin. Stronger, about 4 times stronger.
3) Anti-inflammatory and soothing
Damage to the skin barrier increases the permeability of irritants, which causes cells to produce chemokines and pro-inflammatory factors, ultimately leading to sensitive skin.Consequently, it is possible to prevent or lessen the harm done to skin tissue during the inflammatory response by blocking the synthesis of inflammatory factors and chemokines.
Studies have found that phloretin can inhibit the inflammatory response of RAW264.7 macrophages induced by LPS and has anti-inflammatory effects. It also inhibits the production of inflammatory factors TNF-α, IL-6 and IL-1β. It can inhibit the ability of monocytes to adhere to keratinocytes and hinder the phosphorylation of signaling protein kinases Akt and MAPK, thereby achieving anti-inflammatory effects.
4) Natural sun protection
Ultraviolet irradiation can cause cells to produce reactive oxygen species and free radicals, which are extremely unstable and prone to a series of oxidative chain reactions, ultimately damaging cells.
Phloretin can not only directly absorb ultraviolet rays, but also enhance the expression of nucleotide excision repair genes, slow down the formation of pyrimidine dimers, glutathione degradation and cell death induced by UVB, and reduce the damage of ultraviolet rays to keratinocytes. It has potential application value in sunscreen cosmetics. Adding it to the basic formula of cosmetics can increase the SPF and SPA value of cosmetics.
5) Antibacterial
Phlorizin 98% Free Sample is a flavonoid compound with antibacterial activity. It has broad-spectrum antibacterial activity and has inhibitory effects on a variety of Gram-positive bacteria, Gram-negative bacteria and fungi.
In addition to its antibacterial activity against pathogenic bacteria, it also has an effect on common bacteria on the skin.
Shaanxi Lonier Biotechnology Co., Ltd. is an enterprise dedicated to the production and sales of natural plant extracts, health product raw materials, cosmetic raw materials, pharmaceutical intermediates, etc. Our products have obtained many complete international certificates such as FSSC22000, Kosher, SC, ISO9001, HACCP, HALAL, etc.
Over the years, our company has positioned itself to produce high-quality, exquisite products, and has always adhered to strict product quality testing and control to deliver the best products to customers!
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