In the past few years, bakuchiol has rapidly become popular. Because it has been found in many laboratory studies and clinical trials, it not only has good oil control, anti-inflammatory and anti-acne activities, but also has a strong antioxidant, anti-aging and whitening effect.
Even, Bakuchiol has become an alternative to vitamin A products. You must know that vitamin A is already the first among all the current anti-aging active ingredients. Boseine cannot be compared with vitamin A, and the reason why bakuchiol can be compared with vitamin A is because the two The mechanism of action is very close. It can even be said that the principle of action of vitamin A is the same as that of bakuchiol.
How it works?
1.Regulation of retinoic acid receptors and related genes.
For example, the results of the gene chip can prove that the mode of action of bakuchiol is similar to that of vitamin A in many aspects, and the volcano diagrams of the two are strikingly similar.
Specifically, from the retinoic acid signaling pathway, bakuchiol, like vitamin A, can regulate most of the key genes, such as retinol-binding protein CRBP1, TIG1, etc.
Interestingly, there are some differences between the two. For example, vitamin A can up-regulate the RARB and RARG receptor genes, but bakuchiol does not affect the expression of these two genes. Studies have shown that these two genes are likely to have a certain relationship with skin irritation.
2.Promote collagen production
In the collagen composition of the skin, type I and type III collagen are the main components of the extracellular matrix of the skin, while type IV collagen plays an important role in the skeleton of the basement membrane. In aging or photodamaged skin, the loss of these three types of collagen is also more serious.
The researchers tested bakuchiol and vitamin A alcohol respectively, and found that the effect of bakuchiol on vitamin A is similar, and even the promotion effect of type I and type IV is better than that of vitamin A.
The effect of promoting the production of type IV collagen can also be verified by ELISA test.
3.Inhibit the inflammatory response
Compared with vitamin A, the anti-inflammatory ability of bakuchiol is not only not weak, but even stronger to a certain extent.Protein kinases in our body, such as ERK or p38, are involved in the regulation of a series of inflammatory factors, such as tumor necrosis factor (TNF-α), interleukin IL-6, etc., and other inflammatory mediators, such as nitric oxide ( NO), prostaglandins (PEG2), etc., are also key factors in various inflammatory responses. And bakuchiol is very interesting, the upstream can inhibit the phosphorylation level of the kinase, and the downstream can also reduce the release of inflammatory mediators.
To put it figuratively, bakuchiol just sets a checkpoint at each key intersection of the inflammatory response, so that the inflammatory response at each step cannot continue to progress.
4.The regulation of aquaporins
We talk about the most effective way to moisturize every day, but in reality, many people have no idea how to moisturize their skin. After all, our skin is lipophilic but not hydrophilic. How can water molecules be absorbed?
In other words, who is responsible for moisturizing and moisturizing? Here to introduce a new member - aquaporin AQP family. Aquaporins, as the name suggests, are proteins (genes) responsible for opening channels for water. AQPs allow water molecules to flow smoothly into and out of cells by forming a "channel" of a specific shape. For example, the skin surface of two people has the same water content, but the skin with higher AQP3 expression absorbs more water molecules, so it may have a higher water content.
5.Reduce wrinkles
A number of studies have shown that bakuchiol has an excellent ability to reduce wrinkles.
In 2018, scientists in Spain published clinical trial results, claiming that the use of a three-in-one night cream containing bakuchiol (containing both melatonin and VC-IP) can effectively reduce the depth and area of wrinkles.
A number of studies have shown that bakuchiol has an excellent ability to reduce wrinkles.
In 2018, scientists in Spain published clinical trial results, claiming that the use of a three-in-one night cream containing bakuchiol (containing both melatonin and VC-IP) can effectively reduce the depth and area of wrinkles.For the reduction of wrinkle surface area, the effect of bakuchiol is not much different from that of 0.5% vitamin A (compared to before use, both are significantly different), which also shows that bakuchiol has its strengths.
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