Fructus Toosendan Extract is a brown powder extracted from Fructus Toosendan. Our products are made from high-quality raw materials from Fructus Toosendan. They are refined through filtration, concentration, purification and other steps, effectively preserving the active ingredients of toodandan. Its main functions are to repel insects, clear liver fire and relieve pain, so it is widely used in health care products and pharmaceutical raw materials.
Szechwan Chinaberry Fruit Extract nutritional value
Melanin contains the active ingredient of azadirachtin in repelling ascariasis, as well as a variety of bitter triterpene components, azadirachtin, azadirachtin, 21-O-acetyl azadirachtin, and 21-O-methyl azadirachtin. Five alcohols.
1) The main active ingredient in Fructus Toosendan Extract is toosendanin, which has the effect of repelling roundworms. When used together with other insecticides, it can relieve abdominal pain caused by roundworms. People who suffer from damp heat suffer from vaginal itching, which is mostly related to trichomoniasis. Using it can kill insects and relieve itching.
2) Record phrenic nerve discharge and diaphragm muscle electromyography in rats to observe the effect of toosendanin on respiration. The results show that the respiratory failure caused by high doses of toosendanin is mainly due to its inhibitory effect on the central nervous system.
3) Szechwan Chinaberry Fruit Extract has the effect of promoting intestinal muscle tone and can cause spasmodic contractions and cause abdominal pain and diarrhea. Therefore, it is not necessary to use laxatives when expelling roundworms.
4) The combination of toosendanin and anti-venom serum can significantly reduce the dosage of anti-venom serum. Azadirachtin can resist the inhibitory effect of botulinum toxin at the nerve-muscle junction.
Chuan Lian Zi Extract Pharmacological effects
1)Effect on cardiovascular system
The extract of toosendanin can cause abnormal cardiac contraction rhythm in isolated frogs, which can automatically recover after 1 hour. Intravenous injection of toosendanin has no obvious effect on the cardiovascular system of rabbits. Toosendanin acts on the voltage-dependent Ca2+ channels of guinea pig ventricular myocytes. It irreversibly increases the Ca2+ current. Its facilitative effect on L-type calcium channels is achieved by changing the channel voltage sensitivity and prolonging the channel opening time.
2) Effect on digestive system
Toosendanin can increase the muscle tone of rabbit intestines in vitro and in situ, and can also cause spasmodic contraction of intestinal muscles at higher concentrations. At the same time, this effect is not blocked by atropine and can be inhibited by Diphenhydramine antagonizes the release of amines, suggesting that toosendanin has a histamine-like or/and histamine-releasing effect on intestinal muscle.
3)Antibacterial, anti-inflammatory and analgesic effects
In vitro experimental studies have shown that the aqueous extract of Melanina indica has inhibitory effects on Trichophyton violaris, Trichophyton auranthus, Candida albicans, and Staphylococcus aureus. In addition, the components isolated from the oil have significant anti-arthritic pharmacological activity and significant antihistamine effects. Ji Qinghua et al. used the mouse twisting method and the hot plate method to study the analgesic effects of different processed products of Solanum Toodandanii. The results showed that the different processed products of Toosanachachakraside have significant analgesic effects. The anti-inflammatory effects of mice with ear swelling caused by croton oil were compared. The results showed that all processed products had anti-inflammatory effects, among which salt products had the strongest analgesic and anti-inflammatory effects.
4)Anti-tumor effect
In recent years, Chinese scholars have conducted extensive research on the anti-tumor effects of toosendanin, and found that toosendanin can induce cell differentiation, inhibit the proliferation and apoptosis of various tumor cells, and has broad-spectrum anti-tumor effects. Sodium toosendan has a significant inhibitory effect on human cervical cancer, and toosendanin has strong cytotoxicity to human cancer cell lines. Toosendanin extract can inhibit the proliferation and induce apoptosis of human leukemia K562 cells.
5)Antioxidant effect
He Liang et al. used alcohol extraction and water extraction methods to obtain total flavonoids and total polysaccharides from Solanum Toosendan, and experimental studies proved that at appropriate concentrations, both total flavonoids and total polysaccharides showed strong elimination. Free radical capacity, thus proving the antioxidant capacity of toodandan.
6)Inhibit osteoclasts
Zhou Ying et al. used activity as the guide to measure the osteoclast-inhibiting activity of various parts and components of the Melanium toochinata extract. The results showed that the active parts and active components of the Melanium indica have good osteoclast-inhibitory activity.
7)Anthelmintic effect
Chuan Lian Zi Extract has the effect of repelling roundworms, and its active ingredient is toosendanin. Low concentration (1: 5000~9000) of toosendanin has obvious excitatory effect on the whole Ascaris suum and its segments, which is manifested as increased spontaneous activity, intermittent abnormal and violent contractions, and disruption of the movement pattern, lasting for 10 to 24 days. Hour. Toosendanin can also speed up the catabolism of adenosine triphosphate in the worms, resulting in a shortage of energy, leading to contractile spasms and fatigue, and finally preventing the worms from attaching to the intestinal wall and being expelled from the body.
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