Flavonoids are a class of secondary metabolites produced by plants in the long-term natural selection process, and belong to polyphenols. The earliest discovered flavonoids are yellow or light yellow, so they are called flavonoids. Widely present in the roots, stems, leaves, flowers and fruits of higher plants, flavonoids are one of the important subgroups of flavonoids, including luteolin, apigenin and citrus. In addition, flavonoids mainly include kaempferol, quercetin, myricetin, fisetin, etc.
"Flavonoids" are the focus of research and development in the field of nutritional products and medicine at home and abroad. These compounds have obvious application advantages in the traditional Chinese medicine herbal medicine system, and the application direction of related components is also very wide, including skin, inflammation, immunity and other products formula. According to market data released by InsightSLICE, by 2031, the global flavonoids market share is expected to achieve a considerable compound annual growth rate of 5.5%, and the market size will reach 1.45 billion US dollars.
1.Kaempferol is becoming the next potential stock
Kaempferol is a flavonoid found mainly in vegetables, fruits and legumes such as kale, apples, grapes, broccoli, beans, tea and spinach.
According to the terminal products of kaempferol, it is mainly divided into food grade, pharmaceutical grade and other market segments, and pharmaceutical grade currently accounts for a significant proportion.
According to data released by Global Market Insights, 98% of the market demand for kaempferol in the United States comes from the pharmaceutical industry, and functional food and beverages, nutritional supplements, and topical beauty creams are becoming new development directions.
In the nutritional supplement industry, kaempferol is mainly used in immune support and inflammation formulations, and has potential applications in other health fields.
The global market for kaempferol has great potential, with the ingredient currently representing a $5.7 billion global consumer goods market.
At the same time, the ingredient also prevents the spoilage of foods rich in energy-dense nutrients, making it a new-generation antioxidant preservative for specific food or cosmetic applications.
In addition, the ingredient may even be used in agriculture, where researchers conducted intensive research in 2020 as an environmentally friendly crop protection agent, and potential applications are diverse and extend well beyond dietary supplements, food and personal care ingredients.
2."Innovation" of production technology
At present, the global suppliers of kaempferol include Merck Millipore, AppliChem, INDOFINE and TCI Chemicals, etc. The main production process is mainly chemical synthesis. It is reported that most chemically synthesized kaempferol starts from hydroxybenzoic acid, which is the precursor of kaempferol. Hydroxybenzoic acid is primarily derived from phenol and carbon dioxide, both chemicals derived from petroleum and other fossil fuels.
As consumers pay attention to natural and healthy products, how to produce raw materials in a more natural and environmentally friendly process has become a problem that enterprises need to solve.
In late 2021, Danish biotech company Biosyntia and French white biotech company Lantana Bio signed a licensing agreement that will create a new technology platform. According to the agreement between the two companies, the two companies will develop a more sustainable production process of flavonoids through fermentation technology, and Biosyntia will be responsible for the production and commercialization of raw materials. The first commercial raw material is kaempferol.
Not long after this raw material was commercialized, Conagen in the United States also launched kaempferol derived from fermentation technology in early 2022. It starts with sugar extracted from plants and undergoes microbial fermentation through a special process. Microorganisms are used with other organisms. Due to the same biological properties that naturally convert sugar into kaempferol, the entire process avoids the use of fossil fuel derivatives. At the same time, precision fermentation is more sustainable than using products derived from petrochemicals and plant-derived sources.
3.With fermentation technology, Biosyntia lays out "new" market
In order to continue to promote the innovative application of fermentation technology in nutritional raw materials, Biosyntia and Germany's Wacker Group announced in early 2022 that they have signed a contract to develop a large-scale production process for fermentation-derived biotin. The long-term collaboration aims to make fermentation-based biotin available for related product applications, including food and beverages, infant nutrition, nutraceuticals, pet food, animal feed, pharmaceuticals, and cosmetics.
Biosyntia's proprietary microbial technology platform is building a fast-growing active ingredient pipeline for the beauty and nutrition industries, and WACKER brings expertise in biotechnological process development and industrial-scale fermentation to the collaboration. The global biotin market size is expected to reach USD 376 million in 2026, and the biotin currently available in the market is synthetically produced from non-renewable petrochemicals.
At present, the global botanical extract market is worth billions of euros and is growing rapidly at an annual rate of 9%. Fermentation technology is more advantageous in creating sustainable and natural plant-based ingredients that benefit consumers' health. Its production process has a "significantly lower environmental footprint" than competing manufacturers.
This time, the new technology platform established by Biosyntia will develop thousands of flavonoids that are currently difficult to produce in large-scale, sustainable production. Through the development and application of proprietary bioprocesses, businesses and consumers can be competitively provided with a more natural and sustainable alternative to the ingredients commonly used in today's nutraceutical formulations.
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