Product Introduction
S-Adenosyl-L-Methionine (SAMe) is a naturally occurring compound in the body that helps produce and regulate hormones and maintain cell membranes, it is produced from methionine and adenosine triphosphate in the liver. In the United States, it also known as S-adenosyl methionine, S-adenosylmethionine, SAMe or SAM-e and ademetionine in Europe, often abbreviated as SAM and AdoMet. It is commonly used to treat depression, osteoarthritis and liver disease. It has been available as a dietary supplement in the United States since 1999, but has been used as a prescription drug in Italy, Spain and Germany.
Wholesale SAME tosylate disulfate is an important biochemical molecule with multiple physiological functions in the human body. It reacts with a variety of bioactive molecules, regulates a variety of signaling pathways and gene expression in the body, thereby affecting the health of the body. At the same time, its clinical application is also very extensive, and it has been proven to play a positive role in the treatment of different diseases.
LonierHerb Ademetionine Disulfate Tosylate is produced by biological enzymatic conversion method, and the final purification adopts freeze-drying , the whole production process is automated. That comply with EP, USP standards, and had been popular all over the world. The regular dosage form: Lyophilized Powder for Injection, Tablets, Capsules, etc.Welcome to your enquiry at any time.Our SAMe Powder is semi-finished raw materials, and mainly suitable for qualified factories, traders and related distribution enterprises, so we do not recommend personal use directly, please kindly be noted.

Brief Information
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Product Name |
S-Adenosyl-L-methionine Disulfate Tosylate |
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Main Specification |
95.0%~103% |
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Appearance |
White to off-white Powder |
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pH |
1.0 ~2.0 |
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CAS |
97540-22-2 |
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Chemical Formula |
C22H34N6O16S4 |
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Molecular Weight |
766.78 |
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EC Number |
249-946-8 |
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Structural Formula |
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LonierHerb Guarantee
LonierHerb Ltd mainly manufacture kinds of health ingredients .
- All goods are manufactured in GMP standard facilities.
- All goods are released after inspection by our independent laboratory or third party.
- All goods are transported by professional freight companies.
- Natural, no additives
- Allergen Free
- Gluten Free
- GMO Free
- Non-Irradiation
Technical Data Sheet
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Product Name |
S-Adenosyl-L-methionine Disulfate Tosylate |
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CAS |
97540-22-2 |
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Test Items |
Test Standard |
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Appearance |
White to off-white Powder |
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S-Adenosyl-L-methionine Disulfate Tosylate |
95.0 % ~103.0% |
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Identification |
Infrared: Conforms to the Reference Spectrum |
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HPLC: The retention time of the major peak corresponds to the reference sample |
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S, S-Isomer (HPLC) |
≥ 75.0% |
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SAM-e ION (HPLC) |
49.5% ~ 54.7% |
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P-Toluenesulfonic Acid |
21.0% ~ 24.0% |
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Content of Sulfate (SO4) (HPLC) |
23.5% ~ 26.5% |
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Loss on Drying |
≤3.0% |
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Sulphated Ash |
≤0.5% |
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pH |
1.0 ~2.0 |
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Related substances(HPLC): |
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S-adenosyl-L-homocysteine |
∠1.0% |
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Adenine |
∠1.0% |
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Methylthioadenosine |
∠1.5% |
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Adenosine |
∠1.0% |
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Total Impurities |
∠3.5% |
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Heavy Metal |
≤10 ppm |
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Total Aerobic Count |
≤1000cfu/g |
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Yeast and Moulds |
≤100cfu/g |
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E-Coli |
Negative |
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Salmonella |
Negative |
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Staphylococcus Aureus |
Negative |
Safety and Side Effects
Information on the long-term safety of S-Adenosyl-L-Methionine (SAMe) is limited because participants in most studies only took it for a short time. However, in a study of alcohol-related liver disease, participants took it for 2 years, and no serious side effects were reported.
If you are pregnant or nursing a child, if you take medication or other dietary supplements, if you have bipolar disorder or Parkinson‵s disease, if you are HIV positive, do not use S-Adenosylmethionine, or consult your doctor, please use under doctor‵s order.
At present, its side effects are uncommon, and when they do occur, they are usually mild problems, such as nausea or indigestion.

Test Reports from Third Laboratory
We have cooperated with other famous third-party laboratories, such as Eurofins, SGS , we can arrange S-Adenosyl-L-Methionine (SAMe) Free Samples to reinspect according to customer's requirements before shipments. Of course, even to the laboratory designated by the customers.

Package and Delivery Time

What are the benefits of S-Adenosyl-L-Methionine?
1) Promotes positive mood balance
SAMe Adenosyl Methionine could enhance the brain‵s dopamine and serotonin neurotransmitters metabolism and function of information transfer.
2) Joint Health
Raw SAME tosylate disulfate in alleviating pain and improve joint function.
3)A dietary supplement
S Adenosyl Methionine Powder can improves mood, maintains the liver and soothes joints in the US market.
4) Antioxidant
It has good antioxidant activity, can remove free radicals in the body, and delay the aging of cells and tissues.
5) Liver detoxification
It has the effect of promoting liver detoxification, which can help the liver reduce toxins in the body and protect liver function.
6) Protect the nervous system
Bulk SAME tosylate disulfate can protect the normal function of the nervous system and help relieve neuropathic pain, neuritis and other diseases.
7) Regulating immunity
It also has an immunoregulatory effect, which can regulate the function of the immune system and enhance human immunity.
Why choose LonierHerb Factory?l
1) More than 10 years of production experience of Adenosylmethionine and first class modern production equipment to confirm that each batch of goods you received is qualified and complied
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2) With the concept of "Quality First, Integrity First", Shaanxi LonierHerb Bio-Technology Co., Ltd. are strictly performing the standard in production and quality control.
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3) With sufficient inventory, safe and package for long distance transportation, we are ready to arrange shipment for you at any time.
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4) Well-know Shipping Agent will ship the cargs to you safe and fast.
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If you want to buy S-Adenosyl-L-Methionine (SAMe), or need the further information, such SAMe S Adenosyl L Methionine price, COA, Samples , please contact and enquiry to us immediately, your satisfaction is our first priority. THANK YOU ! Email: info@lonierherb.com Whatsapp/Wechat: +86-13289383216
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