Shaanxi LonierHerb Bio-Technology Co., Ltd is one of the most professional manufacturers and suppliers of pentapeptide-18 in China, featured by quality products and good price. Please rest assured to wholesale bulk natural pentapeptide-18 for sale here from our factory. Contact us for free sample.
Product Information
Pentapeptide-18 is a new wrinkle-removing peptide, which is mainly used to treat expression wrinkles caused by facial movements, especially those on the forehead and around the eyes. It is a White or Off-white Powder composed of five amino acid modifications (Tyr-D-Ala-Gly-Phe-Leu).
It mainly prevents the formation of fine lines and wrinkles by stimulating collagen synthesis, weakening muscle contraction, and anti-oxidation and anti-inflammatory effects, then improving skin elasticity and firmness, and delaying the aging process of the skin.
Pentapeptide-18 can bind to enkephalin receptors outside nerve cells and release G protein groups, close calcium ion channels , then vesicles cannot fuse, resulting in blocked acetylcholine release, and neurons are in a non-excited state. Therefore, muscle contraction is weakened, preventing the formation of fine lines and wrinkles.
Its effect is similar to the older and more famous Argireline, which has similar effects but different modes of action. When the two are mixed and work synergistically, they hinder the muscle contraction process at two different stages, making wrinkle removal more comprehensive.
Why choose LonierHerb Cosmetic Peptides ?
1) The working principle is to close the calcium ion channel to avoid muscle contraction, then achieving the effect of reducing wrinkles
2) Non-toxic, non-invasive, a safer new anti-wrinkle peptide
3) High bioavailability
4) High purity, good water solubility

Certificate of Analysis
|
Product Name |
Pentapeptide-18 |
Report Number |
PEN20250748 |
|
CAS No. |
64963-01-5 |
INCI Name |
Pentapeptide-18 |
|
Molecular Formula |
C29H39N5O7 |
Molecular Weight |
569.66 |
|
Batch Quantity |
700g |
Manufacture Date |
2025/07/23 |
|
Batch Number |
PEN250723 |
Expiry Date |
2027/07/22 |
|
Test Items |
Test Standard |
Test Result |
|
|
Purity (HPLC) |
≥95.0% |
98.49% |
|
|
Appearance |
White or Off-white Powder |
Conforms |
|
|
Identity by ESI-MS |
Theoretical MW:569.66 |
Conforms |
|
|
Water |
<7.0 % |
2.09% |
|
|
Lead (Pb) |
≤10.0mg/kg |
Conforms |
|
|
Arsenic (As) |
≤2.0mg/kg |
Conforms |
|
|
Cadmium (Cd) |
≤5.0mg/kg |
Conforms |
|
|
Mercury (Hg) |
≤1.0mg/kg |
Conforms |
|
|
Total Aerobic Count |
≤1000cfu/g |
Conforms |
|
|
Yeast & Moulds |
≤100cfu/g |
Conforms |
|
|
Conclusion |
To be complied with in-house Specification. |
|
|
|
Shelf Life |
2 years when properly stored. |
||
|
Storage |
Keep in dark and cool dry place (-20 to 8°C). |
||
What is the connection between Acetyl Hexapeptide-8 and Pentapeptide-18 ?
Expression lines are a common type of skin wrinkles, mainly caused by repeated contraction of facial muscles. When we are young, the skin has elasticity and tension, and the contraction and relaxation of facial expression muscles have little effect on the skin. However, as we age, the skin gradually loses its elasticity, and the repeated contraction of facial expression muscles causes tiny wrinkles on the skin, which gradually deepen over time.
Pentapeptide-18 is a new active peptide that can replace the in vitro anti-wrinkle mechanism. It works similarly to Argireline, but in a different way. When the two are mixed, the wrinkle removal effect is better, and the dosage of a single peptide can be reduced, reducing potential side effects. Specifically as follows:
Acetyl Hexapeptide-8 acts on the SNARE complex to make it unstable. The SNARE complex is an important membrane protein complex in cells that participates in the release of neurotransmitters and the signal transduction process between cells. When the SNARE complex becomes unstable, in turn affects the release of neurotransmitters and signal transduction, and ultimately leads to the inhibition of muscle contraction.
Calcium ions are an important signaling molecule in cells, and changes in their concentration in cells can trigger a variety of biological effects.However, Pentapeptide effectively avoids the entry of calcium ions by closing calcium ion channels, thereby avoiding the occurrence of muscle contraction.
Third Party Reports
We have cooperated with other famous third-party laboratories, such as Eurofins, SGS , we can arrange Pentapeptide-18 Samples to reinspect according to customers requirements before shipments. Of course, even to the laboratory designated by the customers.

What is the function of the pentapeptide?
1) It can stimulate skin cells to produce more collagen, thereby improving the elasticity and firmness of the skin and reducing the appearance of fine lines and wrinkles.
2) When we make expressions or are under stress, facial muscles contract, which can cause wrinkles on the skin. This peptide can reduce wrinkles on the skin by weakening muscle contraction.
3) It has antioxidant and anti-inflammatory effects. It can remove free radicals in the skin and prevent free radical damage to the skin, thereby delaying the aging process of the skin.
4) It can also inhibit inflammatory reactions and reduce skin redness and pain.
Package and Delivery Time
1) 1~500g/Bottle or according to your request, outer is Carton
2) 2 years when properly stored
3) Keep in dark and cool dry place (-20 to 8 degree )

Other Peptides List
| Promote Hair Growth | |
| Acetyl Hexapeptide-1 | Decapeptide-10 |
| Palmitoyl Tetrapeptide-20 Amide | Biotinoyl Tripeptide-1 |
| Acetyl Tetrapeptide-3 | Myristoyl Dipeptide-13 |
| Octapeptide-2 | Myristoyl Pentapeptide-17 |
| Decapeptide-18 | Myristoyl Hexapeptide-16 |
| Decapeptide-28 | Copper Tripeptide-34 HCl |
| Oligopeptide-54 | Myristoyl Pentapeptide-4 |
| Oligopeptide-71 | Myristoyl Tetrapeptide-12 |
| Anti-wrinkle and Anti-aging | |
| Acetyl Hexapeptide-8 | Copper Tripeptide-1 |
| Tripeptide-9 Citrulline | Tripeptide-1 |
| Pentapeptide-18 | Hexapeptide-3 |
| Pentapeptide-3 | Tripeptide-10 Citrulline |
| Oligopeptide-24 | Hexapeptide-11 |
| Palmitoyl Dipeptide-5 Diaminohydroxybutyrate | Hexapeptide-9 |
| Acetyl Decapeptide-3 | Acetyl Tripeptide-30 Citruline |
| Acetyl Octapeptide-3 | Tripeptide-2 |
| Acetyl Pentapeptide-1 | Tripeptide-3 |
| Acetyl Tetrapeptide-11 | Tripeptide-32 |
| Palmitoyl Hexapeptide-14 | Decarboxy Carnosine HCL |
| Palmitoyl Hexapeptide-12 | Dipeptide-4 |
| Palmitoyl Pentapeptide-4 | Tridecapeptide-1 |
| Palmitoyl Tetrapeptide-7 | Tetrapeptide-1 |
| Palmitoyl Tripeptide-1 | Tetrapeptide-4 |
| Palmitoyl Tripeptide-28 | Pentapeptide-34 Trifluoroacetate |
| Trifluoroacetyl Tripeptide-2 | Acetyl Tripeptide-1 |
| Dipetide diaminobutyroyl Benzylamide diacetate | GHK-Cu Copper Peptide |
| Palmitoyl Tripeptide-5 | Palmitoyl Tetrapeptide-10 |
| Decapeptide-4 | Acetyl Tetrapeptide-9 |
| Palmitoyl Tripeptide-38 | Oligopeptide-1 |
| Caprooyl Tetrapeptide-3 | Oligopeptide-2 |
| Hexapeptide-10 | Oligopeptide-6 |
| Whitening and Removing Freckles | |
| Acetyl Glycy l Beta-Alanine | Oligopeptide-68 |
| Decapeptide-12 | Oligopeptide-34 |
| Hexapeptide-2 | Melanostatin DM |
| Nonapeptide-1 | Tetrapeptide-30 |
| Hexapeptide-33 | Myristoyl Tripeptide-31 |
Factory Certificate

Welcome to LonierHerb Factroy

As a Cosmetic Peptides supplier in China, Pentapeptide-18 is our popular products, we have sent lots of products to our clients in the world, and obtained good reputation, so if you are interesting in it or any other Peptides, please do not hesitate to contact us immediately. Email: info@lonierherb.com Whatsapp/Wechat: +86-13289383216
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