Celandine, also known as Rehmannia chinensis, Niu Hibiscus, Coptidis chinensis, Babujin, and Brokenhearts, is a perennial woody plant of the Papaveraceae celandine genus. 2200 meters of hillside, canyon forest edge lawn or roadside, stone crevice, wolf uses grass as medicine to relieve disease, relieve cough and reduce phlegm, facilitate urination, and dispel toxins. Let’s learn about its functions and effects together.
1. Effects on the nervous system
The chelidonine can inhibit the central nervous system and has a strong effect on the nerve endings. Wholesale Chelidonium Majus Extract has weak sedative and hypnotic effects on the central nervous system. Studies have found that chelidanine and tetrahydrocoptidine have sedative and hypnotic effects. Celandine injection can significantly inhibit the spontaneous activity of mice, and has a synergistic effect with sodium pentobarbital.
Studies have shown that chelidonine has a significant analgesic effect, and it mainly inhibits the late phase integral of formalin-induced pain response, and only has a certain inhibitory effect on the early phase in large doses, suggesting that its analgesic effect is mainly due to peripheral.
2. Anti-tumor effect
It has tumor suppressor activity and can delay the growth of malignant tumors. It has a killing effect on esophageal cancer cells. Modern research has found that the active ingredients of celandine, celandine, coptisine and celandine all have cytotoxic activity. Although chelerythrine and sanguinarine have no cytotoxic activity, they also have antitumor activity. According to research, the synthesis of thiophosphoramide and celandine alkaloids can obtain highly active antitumor substances. Ukrain, a new substance isolated from celandine, also has strong lethality to malignant tumor cells.
3. Effects on the respiratory system
Guinea pig experiments show that celandine can prevent the occurrence of anaphylactic shock or histamine shock, and has antitussive effect. Chelandine also has antiparasympathetic and antihistamine activity.
4. Anti-inflammatory effect
Subcutaneous injection of sanguinarine has the effect of inhibiting carrageenan-induced foot swelling in rats.
5. Antibacterial and antiviral effects
The total alkaloids of celandine have antimicrobial effect and can inhibit Gram-positive bacteria, Mycobacterium tuberculosis and fungi in vitro. Celandine and sanguinarine inhibit Gram-positive bacteria and Candida albicans. It has inhibitory effect on catarrhal bacteria, staphylococcus albus, alpha hemolytic streptococcus, staphylococcus aureus, escherichia coli, tuberculosis bacillus, pertussis bacillus, etc., and also has inhibitory effect on some fungi. It has obvious anti-Streptococcus mutans effect, suggesting that it may have a strong anti-caries effect.
6. Effects on smooth muscle
It can inhibit various smooth muscles, and has obvious antispasmodic effect on smooth muscle spasm in the gastrointestinal tract, bronchus and urinary system. It has a relaxing effect on smooth muscle, and at the same time has a significant effect on relieving smooth muscle spasm, and has obvious antagonistic effect on smooth muscle spasm caused by antigen, histamine, cholinergic drugs (such as pilocarpine) and barium chloride.
7. Effects on the cardiovascular system
It excites the heart, raises blood pressure, and dilates the coronary arteries. Gently but persistently lowers arterial pressure without affecting breathing. β-Homochelidrine can cause a transient drop in blood pressure in animals, slow heart rate, and paralyze the vasomotor center in large doses.
8. Other functions
It has the effect of enhancing the phagocytic function of mouse leukocytes. Chellidine can increase urinary excretion and retain calcium and sodium ions; it can prevent or delay the appearance of anaphylactic shock. Celandine extract has obvious insecticidal effect, and different concentrations of celandine extract have certain insecticidal effect.
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